Department
Departement of Microbiology and biochemistry
Research Interests
Specialized in Departement of Microbiology and biochemistry. Focused on academic and scientific development.
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Recent Publications
Ethnopharmacology, Phytochemistry, and Pharmacology of Santolina rosmarinifolia: A review
they were always at the forefront of all cultures and civilizations as a source of medicine.
Medicinal plants are considered rich sources of secondary compounds, and many modern
medications are derived from them. Santolina is the most diverse genus within the mint
family (Asteraceae), that is widely distributed in the Mediterranean basin and many of its
species are well-known due to their medicinal and culinary uses. The present research
discusses the traditional uses, phytochemical components and biological activities of
Santolina rosmarinifolia. To do so, we carried out a comprehensive review of the articles
available in different online databases published from the past to 2022 (i.e., PubMed, Scopus,
and Web of Science, among others). S. rosmarinifolia has several traditional uses, including
as anti-inflammatory and an antimicrobial agent, among several others, ascribed to it. In
Spain, S. rosmarinifolia’s flowerheads are traditionally used as antipyretic, anti-inflammatory,
antihypertensive and hepatoprotective. In Algeria, this plant is used for the treatment of
dermatoses. The same uses are also reported in Portugal. The phytochemical studies have
revealed the presence of terpenes, including monoterpenes, eudesmane-type sesquiterpenes,
germacrene-type sesquiterpenes, dammarane-type triterpenes, coumarins, and flavonoids as
the main classes of constituents. A study carried out on santolina Essential oil showed
existence of sabinene, β-pinene, myrcene, β-phellandrene, limonene, 1,8-cineole, artemisia
ketone, terpinen-4-ol, capillene, ar-curcumene and β-eudesmol. Monoterpenes like β-
phellandrene, limonene and 1,8-cineole are also identified. In conclusion, this studys provides
much information about the interests of vegetal species: Santolina rosmarinifolia.
Citation
M. BENSLAMA Abderrahim, (2023-06-17), "Ethnopharmacology, Phytochemistry, and Pharmacology of Santolina rosmarinifolia: A review", [national] Séminaire National sur : Biodiversité, Santé et Environnement , Université de Temcen
Algerian medicinal plants : Traditional Uses, Phytochemistry and Pharmacological Activities
Citation
M. BENSLAMA Abderrahim, (2023-05-26), "Algerian medicinal plants : Traditional Uses, Phytochemistry and Pharmacological Activities", [international] Current Drug Research Topics in Pharmacy: Traditional Medicine Talks , Turquie
Activité anti-inflammatoire de quelques plantes médicinales de Kabylie
L'Algérie de part sa grande superficie et ses variations climatiques, donne lieu à une variabilité et une diversité des espèces végétales. Ajoutant à cela que notre pays riche de son patrimoine traditions, nous offre un éventail important et différent de l'usage médicinal fait de ces plantes.
Les molécules bioactives issues de ces plantes, suscitent actuellement un intérêt grandissant dans les domaines pharmaceutique. Le regain d’intérêt en thérapeutique pour ces biomolécules est motivé par le fait qu’elles présentent des effets secondaires limités ou inexistants comparativement aux molécules synthétiques qui en plus de causer de nombreux effets secondaires indésirables présentent des limites thérapeutiques.
Notre étude, qui s’inscrit dans l’optique de valorisation des ressources végétales, a pour objectif, l’évaluation du potentiel anti-inflammatoire de quelques plantes médicinales de Kabylie (carthamus caeruleus, Rosa sempervirens, Lavandula stoechas, Romarinus officinalis, Malva sylvestris, Arbutus unedo). L’appréciation de la capacité anti-inflammatoire des plantes étudiées, a été effectué par le test de stabilisateur des membranes érythrocytaires vis-à-vis de différents stress (osmotique, oxydant induit par le HOCL et la chaleur) et par la stabilisation thermique de la sérum albumine.
La somme des résultats obtenus au cours de cette étude montre clairement que les extraits aqueux de feuilles des plantes étudiées, possèdent un potentiel anti-inflammatoire important. De ce fait, ces plantes constituent une source potentielle de molécules bioactives et ainsi constituent une alternative thérapeutique au traitement de nombreuses pathologies initiées par le stress oxydant.
Citation
M. BENSLAMA Abderrahim, Mk idir, Beunis yussra, , (2023-05-04), "Activité anti-inflammatoire de quelques plantes médicinales de Kabylie", [international] International Seminar on Bioresources and Sustainable Development , Université de Bouira
Activité anti-inflammatoire et antioxydante de citron (Citrus limon)
Citation
M. BENSLAMA Abderrahim, (2022), "Activité anti-inflammatoire et antioxydante de citron (Citrus limon)", [national] Journées scientifique Biodiversité , santé et environnement , Université de Bouira
Phytochemical analysis, Antibacterial effect and the antioxidant activity of Atriplex halumus extracts
Citation
M. BENSLAMA Abderrahim, (2022), "Phytochemical analysis, Antibacterial effect and the antioxidant activity of Atriplex halumus extracts", [international] International Online Conference on Valuation of Alternative Plants, Degraded & Margin , Université, EL- OUED
Isolation, identification and antibacterial activity of endophytic fungi from Marrubium vulgare L
Citation
M. BENSLAMA Abderrahim, (2021), "Isolation, identification and antibacterial activity of endophytic fungi from Marrubium vulgare L", [national] Séminaire national : Bio-ressources: Nutrition, Santé et Environnement. , Université de M'sila
Acute, sub-acute toxicity and antioxidant activities (in vitro and in vivo) of Reichardia picroide crude extract
Aim of the study: To date, there are no studies corroborating both its safety and antioxidant activities. The objective of the present study, thus, was to assess the safety profile of Reichardia picroide methanolic extract (RPE) and as well as on its antioxidant and antihemolytic activities.
Materials and methods: The acute toxicity of RPE was carried out based on OECD guidelines 425. Signs accompanying toxicity and possible death of animals were monitored for two weeks to ascertain the medianlethal dose (LD50) of the RPE. In sub-acute toxicity study, the extract was administered by gavage at the doses of 250, 500 and 1000 mg/kg/day for 21 consecutive days. The antioxidant activity of RPE was investigated through various methods both in vitro and in vivo.
Results: The admistrated doses did not produce mortality or changes in general behaviors of the tested males and females mice. The LD50 was found to be superior to 5000 mg/kg DW. Moreover, daily administration of RPE at doses ranged from 500 to 1000 mg/kg could result in alteration of liver and kidney histology. Significant
decrease in liver enzymes (ALT and AST), urea and creatinine levels in female plasma was recorded. The RPE was, in vitro, strong in DPPH scavenging and hemolytic inhibition, benificial in lipid peroxidation inhibition and reducing power. In addition, it exhibited, in vivo, a strong effect on GSH level increasing and lipid peroxidation inhibition in liver and kidney.
Conclusions: It can be suggested, based on the results of this study, that the crude extract of Reichardia picroide was non-toxic in acute administration and the use of this extract is safe at doses ≤ 250 mg/kg. This study supports the application of Reichardia picroides in alimentary and traditional medicine purposes. Moreover, antioxidant activity results suggested that Reichardia picroide had potent antioxidant activities and could be utilized as new natural antioxidant in food and therapeutics.
Citation
M. BENSLAMA Abderrahim, Sana AOUACHRIA, Sabah BOUMERFEG, Fayçal BENBACHA, Thorya GUEMMAZ, , (2017), "Acute, sub-acute toxicity and antioxidant activities (in vitro and in vivo) of Reichardia picroide crude extract", [national] Journal of Ethnopharmacology , Elsevier
Phenolic Compounds, Antioxidant and Antibacterial Activities of Zizyphus lotus L. Leaves Extracts
Objective: The aim of the present study was to evaluate the antioxidant capacity and antibacterial activity of Zizyphus lotus extracts, which has been used traditionally in folk medicine of Algeria.
Methods: The leaves of plants were submitted to extraction by water and methanol to give methanolic (Met.E) and aqueous (Aq.E). The extracts were analyzed by HPLC-TOF/MS and their antioxidant activity was determined using DPPH and ABTS free radical-scavenging test, when the antibacterial activity was determined using disc diffusion method.
Results: The quantitative analysis of polyphenols and flavonoids content showed that the Met.E had the highest amount (562.04 µg EAG/mg E and 66.34 µg EQ/mg E, respectively). The HPLC-TOF/MS analysis of Met.E reveals the presence of two major compounds, rutin and gentisic acid, when Aq.E contain rutin and quercetin-3-β-D-glucoside as a major compound. Results showed that the Met.E exhibited the highest antiradical activity against DPPH and ABTS free radical with EC50=28.19±0.51 µg/mL, and EC50=3.82±0.03 µg/mL, respectively. Moreover, the Met. E of Z. lotus presents a moderate antibacterial activity against Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis, with inhibition zone ranging from 09 to 13 mm. In addition, The Met.E showed a better MIC against M. luteus and B. subtilis (MIC= 25 µg/mL).
Conclusion: Our results showed that the methanolic extract of Z. lotus reported a considerable antioxidant and antibacterial activities which may be due to their richness on polyphenols and flavonoids.
Keywords: Antioxidant, antibacterial, Z. lotus, phenolic compounds, HPLC-TOF/MS, disc diffusion method, methanolic (Met.E) extract.
Citation
M. BENSLAMA Abderrahim, Fatih GÜL, Ibrahim DEMİRTAŞ, , (2017), "Phenolic Compounds, Antioxidant and Antibacterial Activities of Zizyphus lotus L. Leaves Extracts", [national] The Natural Products Journal , Bentham science
Total phenolic contents, antioxidant and antibacterial activities of Limoniastrum guyonianum (Plombaginaceae) extracts
Citation
M. BENSLAMA Abderrahim, Safia AFISSA, Asma SAIDI, , (2016), "Total phenolic contents, antioxidant and antibacterial activities of Limoniastrum guyonianum (Plombaginaceae) extracts", [national] International Journal of Current Research , akhil kapio
Free radicals scavenging activity and reducing power of two Algerian Sahara medicinal plants extracts.
Citation
M. BENSLAMA Abderrahim, abdenassar.harrara@univ-msila.dz, , (2016), "Free radicals scavenging activity and reducing power of two Algerian Sahara medicinal plants extracts.", [national] International Journal of Herbal Medicine , Akhil Gupta