M. MERZOUGUI Malika

MCB

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Department

Teaching service - Common trunk Nature and Life Sciences

Research Interests

Specialized in Teaching service - Common trunk Nature and Life Sciences. Focused on academic and scientific development.

Contact Info

University of M'Sila, Algeria

Email : merzougui.malika@univ-msila.dz

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Recent Publications

2025-10-18

Improvement of the reactivity of triethyl phosphate and structural behavior of hydroxyapatite versus the synthesis conditions by sol–gel route

Hydroxyapatite (HA) is a biocompatible and bioactive material used as bone-substitute materials in both orthopedics and dentistry. This work is devoted to studying the synthesis of hydroxyapatite (HA) by sol–gel route using triethyl phosphate (TEP) and calcium nitrate tetrahydrate as calcium and phosphor precursors. In order to optimize the hydrolysis of TEP, each prepared solution was aged in a closed Teflon® container. Several factors were tested in order to improve the synthesis conditions of well-crystallized HA. The effect of aging time (4 h, 16 h, and 24 h), aging temperature (25 °C, 50 °C, 70 °C, and 90 °C) of the prepared solutions, and the type of solvents (ethanol and/or distilled water) were tested. All dried gels were calcined at 700 °C for 1 h. The obtained results showed that the crystallinity degree of hydroxyapatite increases with aging time and temperature, which must not exceed 70 °C. When the prepared solutions were aged at 90 °C, the tri-calcium phosphate (TCP) was formed as a major phase and HA was present as a very minor phase. It was remarked that the aging of sols in a closed Teflon container® leads to an important decrease of the aging time and temperature. It was found that 24 h and 70 °C are the optimal conditions for the synthesis of well-crystallized HA. Also, it was deduced that a sufficient amount of water was needed to hydrolyze the triethyl phosphate and consequently, to obtain a well-crystallized HA.
Citation

M. MERZOUGUI Malika, (2025-10-18), "Improvement of the reactivity of triethyl phosphate and structural behavior of hydroxyapatite versus the synthesis conditions by sol–gel route", [national] Chemical Papers , Fatima Zohra Mezahi

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2022-10-24

Caracterisation of doped hydroxyapatite by Magnesium versus the heat treatment temperature

Hydroxyapatite (HA) is a bio-compatible and bioactive ceramic, capable of interacting and bonding chemically with the surrounding bone. Due to its similarity to the mineralized matrix of natural bone (human skeletal system), this inorganic phosphate has been studied extensively for medical application (orthopedics and dentistry) under the form of powders, composites, or prosthetic coatings. Contrary to pure stoichiometric HA, biological apatites are nonstoichiometric, poorly crystalline, and often contain several ionic impurities such as Mg 2+, Na+, Zn2+ and F. These elements are known to play a significant role in bone metabolism, growth, and nutriment absorption. One of the elements associated with biological apatites is magnesium. Mg incorporation into HA stimulates osteoblast proliferation. One of the elements associated with biological apatites is magnesium. Mg incorporation into HA stimulates promotes bone formation and important for biological activity and interaction between bone mineral and calcium–phosphate-based implant materials. the aim of this study is to study the effect of magnesium on the crystallization of hydroxyapatite, chemical structure, thermal behavior and morphological.
Citation

M. MERZOUGUI Malika, (2022-10-24), "Caracterisation of doped hydroxyapatite by Magnesium versus the heat treatment temperature", [international] International seminar in industrial engineering and applied mathematics (isieam 2022) , University of Skikda_Algeria

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2019-06-30

Effect of aging time on synthesis of hydroxyapatite by sol- gel route

Hydroxyapatite (HAP) (Ca10 (PO4)6 (OH)2) is the most common calcium phosphate that has assumed substantial interest and importance because of his similarity to the biological tissue of the bones and teeth [1]. HAP is characterized by his excellent biocompatibility and bioactivity making it one of the most biomaterials applied in the medical domain. the aim of this work is the synthesize hydroxyapatite (HAP) by sol-gel route and the study of the effect of aging time (4 h, 16 h and 24 h) of the prepared solutions which contain the precursors of Ca and P. different analyses were used in order to study the formation of HA and his crystallisation with aging time such as XRD and FTIR. The obtained results have shown that aging at 70°C for 24 hours makes it possible to obtain good crystallized hydroxyapatite after heat treatment at 700°C. But, also a second phase (CaO) was present and the ratio of this phase decreased with aging time. 
Keywords: Hydroxyapatite (HAP), Sol-gel method, aging.
Citation

M. MERZOUGUI Malika, (2019-06-30), "Effect of aging time on synthesis of hydroxyapatite by sol- gel route", [international] The first International Conference on Materials, Environment, Mechanical and Industrial Systems ICMEMIS’19 , University of DJELFA, Algeria

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2018-09-12

Sodium effect on the hydroxyapatite synthesis by the sol-gel route

Hydroxyapatite (HA) Ca10 (PO4)6 (OH)2 is a very important inorganic material; first mineral constituent of bones, tooth enamel and dentin. It is very flexible in terms of composition and morphology. HA is known as a biocompatible, a non-resorbable and a bioactive bioceramic and is mainly used for many medical applications. The aim of this work is devoted to study of the effect of the sodium addition (Na) with different molar ratio (0, 1, 5, 10, 15 and 20%) on the synthesis of hydroxyapatite by the sol-gel route. From the obtained results, it was possible to obtain well crystallized hydroxyapatite at 700 °C. It was synthesized from the following precursors: the calcium nitrate and triethyl phosphate. Sodium nitrates were used as a source of Na. The synthesis was carried out for 3 days; one day for aging the prepared solutions; one day to obtain a gel, one day to dry the gel. The obtained results showed that the addition of sodium stabilize the synthesis of hydroxyapatite by the sol-gel route. As ratio of Na increases, the intensity of the XR peaks of HA increases and that of CaO decreases. Thus, XRD has shown the apparition of a new phase (-CaNaPO4) at 1000 °C and 1300 °C for the large concentrations of Na (15 % and 20 %).
Key words: Hydroxyapatite, Sol-gel route, Sodium.
Citation

M. MERZOUGUI Malika, (2018-09-12), "Sodium effect on the hydroxyapatite synthesis by the sol-gel route", [international] International Conference on Materials Science ICMS2018 , Ferhat ABBAS University SETIF1

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