M. SARA Zerrouki

MCB

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Department

Departement of Chemistry

Research Interests

Specialized in Departement of Chemistry. Focused on academic and scientific development.

Contact Info

University of M'Sila, Algeria

Email : sara.zerrouki@univ-msila.dz

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Recent Publications

2022-12-13

the phytochemical investigation of the n-butanol extract of an asteraceae specie

The aim of this study was the separation, isolation and structural identification of secondary
metabolites contained in the n-BuOH extract of an asteraceae specie. The phytochemical
investigation led to isolation of secondary metabolites from flavonoids classes the identification
of structural was carried out on the analyses of their NMR spectroscopy 1D (1H, 13C), NMR
2D (COSY, HSQC, HMBC). This study could provide a scientific background to the use of the
asteraceae species derivatives as functional ingredients in Algerian traditional medicine.
Citation

M. SARA Zerrouki, (2022-12-13), "the phytochemical investigation of the n-butanol extract of an asteraceae specie", [national] substance naturelle aujourd'hui, médicament prometteur demain , M'sila

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2022-11-06

Phenolic and flavonoid contents and antioxidant activity of Tourneuxia variifolia Coss. extracts (Asteraceae)

Phenolic and flavonoid contents and antioxidant activity of
Tourneuxia variifolia Coss. extracts (Asteraceae)
Citation

M. SARA Zerrouki, (2022-11-06), "Phenolic and flavonoid contents and antioxidant activity of Tourneuxia variifolia Coss. extracts (Asteraceae)", [national] journal of new technology and materiels , journal of new technology and materiels

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2022-02-28

Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts

Although notable medicinal value and biological activities such as antioxidant, antibacterial, antimicrobial
and antifungal of Limoniastrum guyonianum have been reported, identification and quantification of phytoconstituents
of CHCl3, EtOAC, and n-BuOH extracts from the aerial parts of the halophyte medicinal plant from Algerian Sahara
was not well investigated for biological and anticancer activity in spite of their great interest. Therefore, the aim of this
study was to investigate the antioxidant and anticancer activities of L. guyonianum. The phytoconstituents of CHCl3,
EtOAC, and n-BuOH extracts were screened using HPLC-DAD. Total phenolic and flavonoid contents were quantified,
antioxidant activity, using DPPH radical scavenging activity, ABTS+° decolorization, cupric reducing power, and anticancer activity against human cervical adenocarcinoma (HeLa) cell line were investigated and quantified. The results
showed the presence of chlorogenic, gallic, syringic, p-coumaric, trans ferulic, o-coumaric acids, and quercetin in
significant varying quantities. Chlorogenic acid was present in the greatest quantity (344.027–422.711mg/g of extract)
as well as quercetin in CHCl3 extract. It is important to note the absence of caffeic acid and o-coumaric acid from EtOAc
and CHCl3 extracts, respectively. The content of phenolic and flavonoid were higher in EtOAc extract (934±4,38mgGAE
and 218.33±6.36mgQE/gof extract), respectively. EtOAc extract possesses a strong antioxidant effect in vitro, while the
CHCl3 extract proved to be the most active againstHeLa cell lines (IC50= 50.369±0.020µg/ml). The findings in this
studydemostrate the potential use of these compounds in medicine and importance of this species, which have largely
been used in folk medicine for several diseases’ treatment.
Citation

M. SARA Zerrouki, (2022-02-28), "Antioxidant, anticancer activities, and HPLC-DAD analyses of the medicinal halophyte Limoniastrum guyonianum Dur. extracts", [national] Journal of Research in Pharmacy , Journal of Research in Pharmacy

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2021-10-08

LC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts

Several Saharan plants, despite their abundance of natural compounds, have received little attention. In this study, the chemical composition of polar extracts of Tourneuxia variifolia Coss. (Asteraceae), an endemic species to Algerian Sahara, was investigated and their anticancer activity was evaluated in vitro. The phytoconstituents of both ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts were screened using LC/MS-MS technique. The anticancer activity of the above extracts was measured against human cervical adenocarcinoma (HeLa) cell line. The LC/MS-MS analyses results revealed that twenty-seven phytochemicals in EtOAc extract and twenty-three in n-BuOH extract were identified and quantified from which isoquercetin and astragalin were the most present. Moreover; the EtOAc extract was found to have a strong anticancer activity (IC50: 46.797 ± 0.060 µg/mL). These findings identified T. variifolia as a potential plant exhibiting anticancer properties.
Citation

M. SARA Zerrouki, (2021-10-08), "LC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts", [national] Natural Product Research , Natural Product Research

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